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Characterization of a Myostatin-like Gene from the Scallop Patinopecten yessoensis

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dc.contributor.authorHyun-Woo Kim-
dc.contributor.authorMyong Suk Yoo-
dc.contributor.authorKim, Hak Jun-
dc.date.accessioned2018-03-20T13:20:14Z-
dc.date.available2018-03-20T13:20:14Z-
dc.date.issued2007-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/5951-
dc.description.abstractMyostatin (GDF8) is a growth factor that limits muscle tissue growth and development in vertebrates. We isolated a myostatin-like gene (Py-MSTN) from the marine invertebrate the scallop Patinopecten yessoensis. Py-MSTN was highly expressed in the adductor muscle and in the gill unexpectedly. Amino acid analysis showed that Py-MSTN has 49% amino acid sequence identity and 64% similarity to human myostatin (Hs-MSTN), and 42% identity and 61% similarity to myoglianin, the only invertebrate homolog. These results indicated that Py-MSTN may be functionally similar to the vertebrate MSTN than the invertebrate homolog. Phylogenetic analysis suggested that Py-MSTN is an ancestral form of vertebrate MSTN and GDF11 and does not belong to other TGF-ß family members. Molecular modeling showed that Py-MSTN exhibits a similar tertiary structure to mammalian BMP7, a member of TGF-ß family. In addition, the amino acid residues which contact extracellular domain of the receptor were relatively conserved. Given these results, we propose that Py-MSTN is a functionally active member of the TGF-ß family and that it is involved in muscle growth and regulation.-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.titleCharacterization of a Myostatin-like Gene from the Scallop Patinopecten yessoensis-
dc.title.alternative한국산 참가리비에서 분리한 마이오스태틴 유사 유전자의 특성연구-
dc.typeArticle-
dc.identifier.bibliographicCitationHyun-Woo Kim, Myong Suk Yoo, Kim, Hak Jun. 2007. "Characterization of a Myostatin-like Gene from the Scallop Patinopecten yessoensis". <em>The Korean Society of Fisheries and Aquatic Science</em>, 10(1): 16-23.-
dc.citation.titleThe Korean Society of Fisheries and Aquatic Science-
dc.citation.volume10-
dc.citation.number1-
dc.identifier.doi10.5657/FAS.2007.10.1.016-
dc.citation.startPage16-
dc.citation.endPage23-
dc.description.articleClassificationKCI등재-
dc.description.jcrRateJCR 2005:0-
dc.subject.keywordPatinopecten yessoensis-
dc.subject.keywordScallop-
dc.subject.keywordMyostatin-
dc.subject.keywordTGF-β-
dc.subject.keywordMuscle-
dc.subject.keywordFisheries-
dc.identifier.localId2007-0037-
Appears in Collections  
2006-2007, Identification of psychrophilic microalgae secreting an antifreeze protein (06-07) / Kim, Hak Jun (PE06230)
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