Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus

Abstract

Two new polycyclic prenylated xanthones (1 and 2) and a new phenylpropanoid glycoside (3), along with seven known compounds (4？10) were isolated from the fruits of Garcinia xanthochymus. The structures of the new compounds were elucidated by 1D- and 2D-NMR, and HRMS experiments. The isolates were evaluated for their inhibitory effects against the viability of U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor aberrantly active signal transducer and activation of transcription 3 (STAT3), and compared to normal NIH3T3 mouse fibroblasts. Among the isolates, compounds 1, 2, 5, and 6？9 inhibited the viability of glioma cancer cells that harbor aberrantly active STAT3, with IC50 values in the range of 1.6？6.5 ？M. Furthermore, treatment of U251MG with 6 and 7 inhibited intracellular STAT3 tyrosine phosphorylation and glioma cell migration in vitro, respectively.