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Comprehensive Expression Profiling and Functional Network Analysis of Porphyra-334, One Mycosporine-Like Amino Acid (MAA), in Human Keratinocyte Exposed with UV-radiation

Cited 6 time in wos
Cited 5 time in scopus

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dc.contributor.authorSuh, Sung-Suk-
dc.contributor.authorKim, Sanghee-
dc.contributor.authorKim, Il-Chan-
dc.contributor.authorHan, Se Jong-
dc.contributor.authorYoun, Ui Joung-
dc.contributor.authorLee, Sung Gu-
dc.date.accessioned2018-03-20T13:58:32Z-
dc.date.available2018-03-20T13:58:32Z-
dc.date.issued2017-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/6516-
dc.description.abstractMycosporine-like amino acids (MAAs) have been highlighted as pharmacologically active secondary compounds to protect cells from harmful UV-radiation by absorbing its energy. Previous studies have mostly focused on characterizing their physiological properties such as antioxidant activity and osmotic regulation. However, molecular mechanisms underlying their UV-protective capability have not yet been revealed. In the present study, we investigated the expression profiling of porphyra-334-modulated genes or microRNA (miRNAs) in response to UV-exposure and their functional networks, using cDNA and miRNAs microarray. Based on our data, we showed that porphyra-334-regulated genes play essential roles in UV-affected biological processes such as Wnt (Wingless/integrase-1) and Notch pathways which exhibit antagonistic relationship in various biological processes;the UV-repressed genes were in the Wnt signaling pathway, while the activated genes were in the Notch signaling. In addition, porphyra-334-regulated miRNAs can target many genes related with UV-mediated biological processes such as apoptosis, cell proliferation and translational elongation. Notably, we observed that functional roles of the target genes for up-regulated miRNAs are inversely correlated with those for down-regulated miRNAs;the former genes promote apoptosis and translational elongation, whereas the latter function as inhibitors in these processes. Taken together, these data suggest that porphyra-334 protects cells from harmful UV radiation through the comprehensive modulation of expression patterns of genes involved in UV-mediated biological processes, and that provide a new insight to understand its functional molecular networks.-
dc.languageEnglish-
dc.subjectPharmacology & Pharmacy-
dc.titleComprehensive Expression Profiling and Functional Network Analysis of Porphyra-334, One Mycosporine-Like Amino Acid (MAA), in Human Keratinocyte Exposed with UV-radiation-
dc.title.alternative자외선에 노출된 인간 Keratinocyte 세포에서 마이코스포린 유사 아미노산(MAAs)의 일종인 porphyra-334의 포괄적인 발현 프로파일링 및 기능성 네트워크 분석-
dc.typeArticle-
dc.identifier.bibliographicCitationSuh, Sung-Suk, et al. 2017. "Comprehensive Expression Profiling and Functional Network Analysis of Porphyra-334, One Mycosporine-Like Amino Acid (MAA), in Human Keratinocyte Exposed with UV-radiation". <em>MARINE DRUGS</em>, 15: 196-NaN.-
dc.citation.titleMARINE DRUGS-
dc.citation.volume15-
dc.identifier.doi10.3390/md15070196-
dc.citation.startPage196-
dc.citation.endPageNaN-
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2015:22.034-
dc.subject.keywordMycosporine-like amino acids (MAAs)-
dc.subject.keywordNotch pathway-
dc.subject.keywordUV-radiation-
dc.subject.keywordWnt pathway-
dc.subject.keywordmicroRNAs-
dc.subject.keywordporphyra-334-
dc.identifier.localId2017-0094-
dc.identifier.scopusid2-s2.0-85024479129-
dc.identifier.wosid000406685900004-
Appears in Collections  
2017-2018, Large-scale production and Clinical evaluation of CPS (Cell-Protecting Substance) from polar microalgae (17-18) / Kim, Sanghee (PE17180; PE18180)
2016-2018, Cryo-Biotech (16-18) / Yim, Joung Han; Han, Se Jong (PE16190; PE17100; PE18100)
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