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Possible Roles of Antarctic Krill Proteases for Skin Regeneration

Cited 0 time in wos
Cited 2 time in scopus

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dc.contributor.authorLee, Hong Kum-
dc.contributor.authorKoh, Hye Yeon-
dc.contributor.authorLee, Sung Gu-
dc.contributor.authorYim, Joung Han-
dc.coverage.spatialAntarctic-
dc.date.accessioned2018-03-20T13:59:23Z-
dc.date.available2018-03-20T13:59:23Z-
dc.date.issued2008-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/6533-
dc.description.abstractAntarctic krill has a strong proteolytic enzyme system, which comes from a combination of several proteases. This powerful activity can be easily detected by krill's superior post mortem autolysis. Mammalian skin consists of epidermis and dermal connective tissue, and functions as a barrier against threatening environments. A clot in a wound site of the skin should be removed for successful skin regeneration. Epithelial cells secrete proteases to dissolve the clot. In previous studies Antarctic krill proteases were purified and characterized. The proteolytic enzymes from Antarctic krill showed higher activity than mammalian enzymes. It has been suggested that these krill clean up the necrotic skin wound to induce a natural healing ability. The enzymes exhibited additional possibilities for several other biomedical applications, including dental plaque controlling agent and healing agent for corneal alkali burn. Considering that these versatile activities come from a mixture of several enzymes, discovering other proteolytic enzymes could be another feasible way to enhance the activity if they can be used together with krill enzymes. Molecular cloning of the krill proteases should be carried out to study and develop the applications. This review introduces possible roles of the unique Antarctic krill proteases, with basic information and suggestion for the development of an application to skin regeneration.-
dc.languageEnglish-
dc.publisher한국해양연구원-
dc.subjectOceanography-
dc.titlePossible Roles of Antarctic Krill Proteases for Skin Regeneration-
dc.title.alternative피부세포 재생을 위한 남극크릴유래 단백질분해효소의 기능-
dc.typeArticle-
dc.identifier.bibliographicCitationLee, Hong Kum, et al. 2008. "Possible Roles of Antarctic Krill Proteases for Skin Regeneration". <em>Ocean and Polar Research</em>, 30(4): 467-472.-
dc.citation.titleOcean and Polar Research-
dc.citation.volume30-
dc.citation.number4-
dc.identifier.doi10.4217/OPR.2008.30.4.467-
dc.citation.startPage467-
dc.citation.endPage472-
dc.description.articleClassificationKCI등재-
dc.description.jcrRateJCR 2006:0-
dc.subject.keywordAntarctic-
dc.subject.keywordDebridement-
dc.subject.keywordKrill-
dc.subject.keywordSkin regeneration-
dc.identifier.localId2008-0221-
dc.identifier.scopusid2-s2.0-5814937396-
Appears in Collections  
2006-2010, Procurement and utilization of polar genetic resources (06-10) / Lee, Hong Kum; Yim, Joung Han (PE06050, PE07050, PE08050, PE09050, PE10050)
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