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Synthesis of Cyclic Antifreeze Glycopeptide and Glycopeptoids and Their Ice Recrystallization Inhibition Activity

Cited 5 time in wos
Cited 5 time in scopus

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dc.contributor.authorRavichandran N. Murugan-
dc.contributor.authorKim, Eunjung-
dc.contributor.authorJeong Kyu Bang-
dc.contributor.authorKim, Hak Jun-
dc.contributor.authorMija Ahn-
dc.contributor.authorLee, Jun Hyuck-
dc.contributor.authorSong Yub Shin-
dc.date.accessioned2018-03-20T14:00:36Z-
dc.date.available2018-03-20T14:00:36Z-
dc.date.issued2012-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/6549-
dc.description.abstractUntil now, few groups reported the antifreeze activity of cyclic glycopeptides;however, the tedious synthetic procedure is not amenable to study the intensive structure activity relationship. A series of N-linked cyclic glycopeptoids and glycopeptide have been prepared to evaluate antifreeze activity as a function of peptide backbone cyclization and methyl stereochemical effect on the rigid Thr position. This study has combined the cyclization protocol with solid phase peptide synthesis and obtained significant quantities of homogeneous cyclic glycopeptide and glycopeptoids. Analysis of antifreeze activity revealed that our cyclic peptide demonstrated RI activity while cyclic glycopeptoids showed no RI activity. These results suggest that the subtle changes in conformation and Thr orientation dramatically influence RI activity of N-linked glycopeptoidsnd glycopeptide have been prepared to evaluate antifreeze activity as a function of peptide backbone cyclization and methyl stereochemical effect on the rigid Thr position. This study has combined the cyclization protocol with solid phase peptide synthesis and obtained significant quantities of homogeneous cyclic glycopeptide and glycopeptoids. Analysis of antifreeze activity revealed that our cyclic peptide demonstrated RI activity while cyclic glycopeptoids showed no RI activity. These results suggest that the subtle changes in conformation and Thr orientation dramatically influence RI activity of N-linked glycopeptoids-
dc.languageEnglish-
dc.publisherKorean Chemical Society-
dc.subjectChemistry-
dc.titleSynthesis of Cyclic Antifreeze Glycopeptide and Glycopeptoids and Their Ice Recrystallization Inhibition Activity-
dc.title.alternativeAntifreeze Glycopeptide 유도체 합성 및 합성된 물질의 결빙방지활성 측정-
dc.typeArticle-
dc.identifier.bibliographicCitationRavichandran N. Murugan, et al. 2012. "Synthesis of Cyclic Antifreeze Glycopeptide and Glycopeptoids and Their Ice Recrystallization Inhibition Activity". <em>BULLETIN OF THE KOREAN CHEMICAL SOCIETY</em>, 33(11): 3565-3570.-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume33-
dc.citation.number11-
dc.identifier.doi10.5012/bkcs.2012.33.11.3565-
dc.citation.startPage3565-
dc.citation.endPage3570-
dc.description.articleClassificationSCI-
dc.description.jcrRateJCR 2010:57.14285714285714-
dc.subject.keywordCyclic glycopeptide-
dc.subject.keywordCyclic glycopeptoid-
dc.subject.keywordIce recrystallization inhibiti-
dc.subject.keywordSolid phase synthesis-
dc.identifier.localId2012-0442-
dc.identifier.scopusid2-s2.0-84870045423-
dc.identifier.wosid000311816000008-
Appears in Collections  
2012-2013, Physical & Bio-geochemical Processes in the Polar Sea Ice Regions: Their Roles & Responses in Global Climate Change (12-13) / Lee, Sang H. (PP12010; PP13020)
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