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Anti-inflammatory activity of compounds from the rhizome of Cnidium officinale

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Anti-inflammatory activity of compounds from the rhizome of Cnidium officinale
Other Titles
Cnidium officinale에서 항염 화합물 분리 보고
Huynh, Nguyen Khanh Tran
Cao, Thao Quyen
Kim, Jeong Ah
Youn, Ui Joung
Kim, Sanghee
Woo, Mi Hee
Min, Byung Sun
Pharmacology & Pharmacy
Cnidium officinale; Umbelliferae; Anti-inflammatory; NO inhibition
Issue Date
Huynh Nguyen Khanh Tran, et al. 2018. "Anti-inflammatory activity of compounds from the rhizome of Cnidium officinale". ARCHIVES OF PHARMACAL RESEARCH, 41(10): 977-985.
Abstract Five new compounds, 9,30-dimethoxyhierochin A (1), 6-oxo-trans-neocnidilide (2), (±)-(3E)-trans-6-hydroxy-7-methoxydihydroligustilide (3), (±)-cnidiumin (4), and 6-(1-oxopentyl)-salicylic acid methyl ester (5), together with twenty known compounds (6?25), were isolated from the rhizome of Cnidium officinale. The chemical structures of new compounds were established by NMR spectroscopic techniques, mass spectrometry, Mosher’s method, and CD spectrum. Their anti-inflammatory activities were evaluated against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW 264.7 cells. Compounds 7, 13, and 14 showed inhibitory effects with IC50 values of 5.1, 24.5, and 27.8 lM, respectively. In addition, compounds 7, 13, and 14 reduced LPS-induced inducible nitric oxide synthase (iNOS) expression and cyclooxygenase-2 (COX-2) protein in a concentration-dependent manner.
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