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Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke

Cited 1 time in wos
Cited 3 time in scopus
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Title
Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke
Other Titles
허혈성 뇌졸중의 치료가능시간을 증가시키기 위한 키토산 코팅 C-Pc 리포좀 개발
Authors
Goo, Yong Chung
Shim, Kyou Hee
Kim, Hye Jin
Min, Seul Ki
Shin, Hwa Sung
Subject
Pharmacology & Pharmacy
Keywords
Brain stroke; C-phycocyanin; Chitosan; Ischemia and reperfusion; Liposome; Neuroprotection
Issue Date
2018-10
Citation
Goo, Yong Chung, et al. 2018. "Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke". CURRENT PHARMACEUTICAL DESIGN, 24(17): 1859-1864.
Abstract
The time window for neuroprotection during ischemic brain stroke is short, and hence, development of neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan- coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity.
URI
https://repository.kopri.re.kr/handle/201206/10874
DOI
http://dx.doi.org/10.2174/1381612824666180515123543
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