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Taking Advantage of Promiscuity of Cold-Active Enzymes

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Taking Advantage of Promiscuity of Cold-Active Enzymes
Other Titles
생명공학적 활용에서의 장점을 가지는 저온성 효소의 특성인 기질 유연성
Nandanwar, Sondavid K.
Borkar, Shweta Bharat
Lee, Jun Hyuck
Kim, Hak Jun
Chemistry; Engineering; Materials Science; Physics
cold-active enzyme; catalytic efficiency; broad substrate specificity; substrate promiscuity; psychrophile
Issue Date
Nandanwar, Sondavid K., et al. 2020. "Taking Advantage of Promiscuity of Cold-Active Enzymes". APPLIED SCIENCES-BASEL, 10(22): 8128-8145.
Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing structural flexibility at or near the active sites. Inevitably, this feat seems to be accompanied by lower thermal stability. These characteristics have made cold-active enzymes into attractive targets for the industrial applications, since they could reduce the energy cost in the reaction, attenuate side-reactions, and simply be inactivated. In addition, the increased structural flexibility could result in broad substrate specificity for various non-native substrates, which is called substrate promiscuity. In this perspective, we deal with a less addressed aspect of cold-active enzymes, substrate promiscuity, which has enormous potential for semi-synthesis or enzymatic modification of fine chemicals and drugs. Further structural and directed-evolutional studies on substrate promiscuity of cold-active enzymes will provide a new workhorse in white biotechnology.
Appears in Collections  
2020-2020, Development of potential candidates as antibiotics based on polar genetic resources (20-20) / Lee, Jun Hyuck (PM20030)
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