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Taking Advantage of Promiscuity of Cold-Active Enzymes

Cited 9 time in wos
Cited 8 time in scopus
Title
Taking Advantage of Promiscuity of Cold-Active Enzymes
Other Titles
생명공학적 활용에서의 장점을 가지는 저온성 효소의 특성인 기질 유연성
Authors
Nandanwar, Sondavid K.
Borkar, Shweta Bharat
Lee, Jun Hyuck
Kim, Hak Jun
Subject
ChemistryEngineeringMaterials SciencePhysics
Keywords
cold-active enzymecatalytic efficiencybroad substrate specificitysubstrate promiscuitypsychrophile
Issue Date
2020-11
Citation
Nandanwar, Sondavid K., et al. 2020. "Taking Advantage of Promiscuity of Cold-Active Enzymes". APPLIED SCIENCES-BASEL, 10(22): 8128-8145.
Abstract
Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing structural flexibility at or near the active sites. Inevitably, this feat seems to be accompanied by lower thermal stability. These characteristics have made cold-active enzymes into attractive targets for the industrial applications, since they could reduce the energy cost in the reaction, attenuate side-reactions, and simply be inactivated. In addition, the increased structural flexibility could result in broad substrate specificity for various non-native substrates, which is called substrate promiscuity. In this perspective, we deal with a less addressed aspect of cold-active enzymes, substrate promiscuity, which has enormous potential for semi-synthesis or enzymatic modification of fine chemicals and drugs. Further structural and directed-evolutional studies on substrate promiscuity of cold-active enzymes will provide a new workhorse in white biotechnology.
URI
https://repository.kopri.re.kr/handle/201206/11817
DOI
http://dx.doi.org/10.3390/app10228128
Type
Article
Station
Dasan Station
Indexed
SCIE
Appears in Collections  
2020-2020, Development of potential candidates as antibiotics based on polar genetic resources (20-20) / Lee, Jun Hyuck (PM20030)
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