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Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island

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dc.contributor.authorMin, Seul Ki-
dc.contributor.authorKim, Jung Eun-
dc.contributor.authorHong, Ju-Mi-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorPark, Hyun-
dc.contributor.authorYoun, Ui Joung-
dc.contributor.authorHan, Se Jong-
dc.contributor.authorKim, Il-Chan-
dc.date.accessioned2021-05-07T07:34:16Z-
dc.date.available2021-05-07T07:34:16Z-
dc.date.issued2020-08-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/11873-
dc.description.abstractChronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the evelopment of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopolysaccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1β and 1α (IL-6, IL-1β and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.en_US
dc.languageEnglishen_US
dc.language.isoen_USen_US
dc.subjectBiotechnology & Applied Microbiologyen_US
dc.subject.classificationKing Sejong Stationen_US
dc.titleAnti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Islanden_US
dc.title.alternative남극 세종과학기지 주변에 서식하는 지의류 추출물의 항면역 효과en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationMin, Seul Ki, et al. 2020. "Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island". <em>BIOTECHNOLOGY AND BIOPROCESS ENGINEERING</em>, 25(4): 543-550.en_US
dc.citation.titleBIOTECHNOLOGY AND BIOPROCESS ENGINEERINGen_US
dc.citation.volume25en_US
dc.citation.number4en_US
dc.identifier.doi10.1007/s12257-019-0371-4-
dc.citation.startPage543en_US
dc.citation.endPage550en_US
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2018:82.716en_US
dc.subject.keywordLecania gerlacheien_US
dc.subject.keywordlichensen_US
dc.subject.keywordAntarcticaen_US
dc.subject.keywordanti-inflammatory propertiesen_US
dc.subject.keywordnuclear factor kappa B (NF-κB) pathwayen_US
dc.identifier.localId2020-0119-
dc.identifier.scopusid2-s2.0-85088284709-
dc.identifier.wosid000550999700001-
Appears in Collections  
2020-2020, Commercialization of new Biomaterials from polar organisms (20-20) / Yim, Joung Han (PE20010)
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