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Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells

Cited 6 time in wos
Cited 7 time in scopus
Title
Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells
Other Titles
NF-κB 신호를 이용한 Terrein의 lipopolysaccharide에 유도된 신경세포 염증 억제
Authors
Kim, Kwan-Woo
Kim, Hye Jin
Sohn, Jae Hak
Yim, Joung Han
Kim, Youn-Chul
Oh, Hyuncheol
Subject
Pharmacology & Pharmacy
Keywords
TerreinAnti-neuroinflammatory effectsNF-kappa BHO-1Nrf2
Issue Date
2020-07
Citation
Kim, Kwan-Woo, et al. 2020. "Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells". JOURNAL OF PHARMACOLOGICAL SCIENCES, 143(3): 209-218.
Abstract
In the course of our continuous investigation on the bioactive marine-derived fungal metabolites, terrein was isolated from marine-derived fungal strain Penicillium sp. SF-7181. Terrein inhibited the overproduction of pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2), as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)stimulated BV2 and primary microglial cells. This compound also repressed the LPS-induced production of pro-inflammatory cytokines, interleukin (IL)-1 beta and IL-6. These inhibitory effects of terrein were associated with the inactivation of the nuclear factor kappa B (NF-kappa B) pathway through suppression of the translocation of p65/p50 heterodimer into the nucleus, the phosphorylation and degradation of inhibitor kappa B (IkB)-alpha and the DNA binding activity of the p65 subunit. In addition, terrein induced the protein expression of heme oxygenase (HO)-1 through the activation of nuclear transcription factor erythroid-2 related factor 2 (Nrf2) in BV2 and primary microglial cells. The anti-inflammatory effect of terrein was blocked by pre-treatment with a selective HO-1 inhibitor, suggesting that its antineuroinflammatory effect is mediated by HO-1 induction. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
URI
https://repository.kopri.re.kr/handle/201206/13028
DOI
http://dx.doi.org/10.1016/j.jphs.2020.01.011
Type
Article
Station
Araon
Indexed
SCI
Appears in Collections  
2020-2020, Commercialization of new Biomaterials from polar organisms (20-20) / Yim, Joung Han (PE20010)
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