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PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394

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Title
PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394
Other Titles
남극 곰팡이 Acremonium sp. SF-7394 유래 이차 대사산물의 PTP1B 억제
Authors
Kim, Hye Jin
Li, Xiao-Jun
Kim, Dong-Cheol
Kim, Tai Kyoung
Sohn, Jae Hak
Kwon, Haeun
Lee, Dongho
Kim, Youn-Chul
Yim, Joung Han
Oh, Hyuncheol
Subject
Biochemistry & Molecular BiologyChemistry
Keywords
Acremonium spterpenoidsAntarctic fungal metabolitesPTP1B
Issue Date
2021-09
Citation
Kim, Hye Jin, et al. 2021. "PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394". MOLECULES, 26(18): 5505-5514.
Abstract
Chemical investigation of the Antarctic lichen-derived fungal strain Acremonium sp. SF-7394 yielded a new amphilectane-type diterpene, acrepseudoterin (1), and a new acorane-type sesquiterpene glycoside, isocordycepoloside A (2). In addition, three known fungal metabolites, (-)-ternatin (3), [D-Leu]-ternatin (4), and pseurotin A (5), were isolated from the EtOAc extract of the fungal strain. Their structures were mainly elucidated by analyzing their NMR and MS data. The absolute configuration of 1 was proposed by electronic circular dichroism calculations, and the absolute configuration of the sugar unit in 2 was determined by a chemical method. The inhibitory effects of the isolated compounds on protein tyrosine phosphatase 1B (PTP1B) were evaluated by enzymatic assays; results indicated that acrepseudoterin (1) and [D-Leu]-ternatin (4) dose-dependently inhibited the enzyme activity with IC50 values of 22.8 +/- 1.1 mu M and 14.8 +/- 0.3 mu M, respectively. Moreover, compound 1 was identified as a competitive inhibitor of PTP1B.
URI
https://repository.kopri.re.kr/handle/201206/13268
DOI
http://dx.doi.org/10.3390/molecules26185505
Type
Article
Station
King Sejong Station
Indexed
SCIE
Appears in Collections  
2021-2021, Commercialization of new Biomaterials from polar organisms (21-21) / Yim, Joung Han (PE21150)
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