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Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes

Cited 2 time in wos
Cited 1 time in scopus
Title
Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes
Other Titles
남극 곰팡이 Pleosporales sp. SF-7343 대사 산물의 HaCaT 각질형성세포에 대한 항염증 효과
Authors
Dong, Linsha
Kim, Hye Jin
Cao, Thao Quyen
Liu, Zhiming
Lee, Hwan
Ko, Wonmin
Kim, Youn-Chul
Sohn, Jae Hak
Kim, Tai Kyoung
Yim, Joung Han
Lee, Dong-Sung
Oh, Hyuncheol
Subject
Biochemistry & Molecular BiologyChemistry
Keywords
Antarctic fungiinflammationICAM-1NF-kappa BHO-1HaCaT
Issue Date
2021-06
Citation
Dong, Linsha, et al. 2021. "Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes". INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(18): 1-14.
Abstract
Chemical investigation of the Antarctic fungi Pleosporales sp. SF-7343 revealed four known secondary fungal metabolites: alternate C (1), altenusin (2), alternariol (3), and altenuene (4). The compound structures were identified primarily by NMR and MS analyses. Atopic dermatitis, an inflammatory disease, is driven by the abnormal activation of T helper (Th) 2 cells and barrier dysfunction. We attempted to identify the anti-inflammatory components of SF-7343. Initial screening showed that compounds 1 and 3 inhibited the secretion of interleukin-8 and -6 in tumor necrosis factor-alpha/interferon-gamma-treated HaCaT cells, and these compounds also showed inhibitory effects on CCL5 and CCL22. Compounds 1 and 3 also downregulated the protein expression levels of intercellular adhesion molecule-1 and upregulated the expression of filaggrin and involcurin. The mechanism study results showed that compounds 1 and 3 inhibited nuclear translocation of nuclear factor-kappa B p65 and the phosphorylation of STAT1 and STAT3. Compound 1, but not compound 3, significantly promoted the expression of heme oxygenase (HO)-1. The effects of compound 1 were partly reversed by co-treatment with a HO-1 inhibitor, tin protoporphyrin IX. Taken together, this study demonstrates the potential value of Antarctic fungal strain SF-7343 isolates as a bioresource for bioactive compounds to prevent skin inflammation.
URI
https://repository.kopri.re.kr/handle/201206/13270
DOI
http://dx.doi.org/10.3390/ijms22189674
Type
Article
Station
King Sejong Station
Indexed
SCIE
Appears in Collections  
2021-2021, Commercialization of new Biomaterials from polar organisms (21-21) / Yim, Joung Han (PE21150)
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