KOPRI Repository

A new α-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells

Cited 0 time in wos
Cited 0 time in scopus
Title
A new α-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells
Other Titles
Arthrinium pseudosinense에서의 새로운 α-pyrone 와 MCF-7 세포에서 에스트로겐 활성
Authors
Kwon, Haeun
Nguyen, Quynh Nhu
Na, Myung Woo
Kim, Ki Hyun
Guo, Yuanqiang
Yim, Joung Han
Shim, Sang Hee
Kim, Jae-Jin
Kang, Ki Sung
Lee, Dongho
Subject
Biotechnology & Applied MicrobiologyImmunologyMicrobiologyPharmacology & Pharmacy
Issue Date
2021-12
Citation
Kwon, Haeun, et al. 2021. "A new α-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells". JOURNAL OF ANTIBIOTICS, 74(12): 893-897.
Abstract
A new α-pyrone analog, arthrifuranone A (1) was isolated from an EtOAc-extract of Arthrinium pseudosinense culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using MS and NMR spectroscopic techniques, and the absolute configuration was established by the Mosher’s method and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4 + analysis. The isolated compound was evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells. Compound 1 showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 3.125 μM via phosphorylation of estrogen receptor-α.
URI
https://repository.kopri.re.kr/handle/201206/13271
DOI
http://dx.doi.org/10.1038/s41429-021-00473-8
Type
Article
Station
King Sejong Station
Indexed
SCIE
Appears in Collections  
2021-2021, Commercialization of new Biomaterials from polar organisms (21-21) / Yim, Joung Han (PE21150)
Files in This Item

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse