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Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense

Cited 1 time in wos
Cited 1 time in scopus
Title
Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense
Other Titles
Penicillium bialowiezense 유래의 항염증 spiroditerpenoids
Authors
Kwon, Jaeyoung
Kim, Min Jee
Kim, Dong-Cheol
Kwon, Haeun
Ryu, Seung Mok
Shim, Sang Hee
Guo, Yuanqiang
Hong, Seung-Beom
Yim, Joung Han
Kim, Youn-Chul
Oh, Hyuncheol
Lee, Dongho
Subject
Biochemistry & Molecular BiologyChemistry
Keywords
Penicillium bialowiezenseSpiroditerpenoidBrevioneAnti-inflammatory effect
Issue Date
2021-08
Citation
Kwon, Jaeyoung, et al. 2021. "Anti-inflammatory spiroditerpenoids from Penicillium bialowiezense". BIOORGANIC CHEMISTRY, 113: 1-7.
Abstract
Inflammation is a vital process that maintains tissue homeostasis. However, it is widely known that uncontrolled inflammation can contribute to the development of various diseases. This study aimed to discover anti inflammatory metabolites from Penicillium bialowiezense. Seven spiroditerpenoids, including two new com pounds, breviones P and Q (1 and 2), were isolated and characterized by various spectroscopic and spectrometric methods. All isolated compounds were initially tested for their inhibitory effects against lipopolysaccharide induced nitric oxide (NO) production in RAW 264.7 macrophages. Of these, brevione A (3) exhibited this ac tivity with a half-maximal inhibitory concentration value of 9.5 μM. Further mechanistic studies demonstrated that 3 could suppress the expression of pro-inflammatory cytokines and mediators, such as NO, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12 by inhibiting the activation of nuclear factor-kappa B and c-Jun N-terminal kinase.
URI
https://repository.kopri.re.kr/handle/201206/13272
DOI
http://dx.doi.org/10.1016/j.bioorg.2021.105012
Type
Article
Station
King Sejong Station
Indexed
SCIE
Appears in Collections  
2021-2021, Commercialization of new Biomaterials from polar organisms (21-21) / Yim, Joung Han (PE21150)
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