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Molecular basis of dimerization of lytic transglycosylase revealed by the crystal structure of MltA from Acinetobacter baumannii

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Title
Molecular basis of dimerization of lytic transglycosylase revealed by the crystal structure of MltA from Acinetobacter baumannii
Other Titles
병원균 (Acinotobacter baumannii) 유래 MltA 단백질의 구조 분석을 통한 이량체 형성과 활성기작 연구
Authors
Jang, Hyunseok
Do, Hackwon
Kim, Chang Min
Kim, Gi Eob
Lee, Jun Hyuck
Park, Hyun Ho
Subject
ChemistryCrystallographyMaterials Science
Keywords
Acinetobacter baumanniicrystal structureMltAlytic transglycosylasespeptidoglycan remodelingsuperbugs
Issue Date
2021-11
Citation
Jang, Hyunseok, et al. 2021. "Molecular basis of dimerization of lytic transglycosylase revealed by the crystal structure of MltA from Acinetobacter baumannii". IUCrJ, 8: 921-930.
Abstract
Peptidoglycan digestion by murein-degrading enzymes is a critical process in bacterial cell growth and/or cell division. The membrane-bound lytic murein transglycosylase A (MltA) is a murein-degrading enzyme; it catalyzes the cleavage of the beta-1,4-glycosidic linkage between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycans. Although substrate recognition and cleavage by MltA have been examined by previous structural and mutagenesis studies, the overall mechanism of MltA in conjunction with other functionally related molecules on the outer membrane of bacterial cells for peptidoglycan degradation has remained elusive. In this study, the crystal structure of MltA from the virulent human pathogen Acinetobacter baumannii is characterized and presented. The study indicated that MltA from A. baumannii forms homodimers via an extra domain which is specific to this species. Furthermore, the working mechanism of MltA with various functionally related proteins on the bacterial outer membrane was modeled based on the structural and biochemical analysis.
URI
https://repository.kopri.re.kr/handle/201206/13567
DOI
http://dx.doi.org/10.1107/S2052252521008666
Type
Article
Station
해당사항없음
Indexed
SCIE
Appears in Collections  
2021-2021, Development of potential candidates as antibiotics based on polar genetic resources (21-21) / Lee, Jun Hyuck (PM21030)
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