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Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration

Cited 2 time in wos
Cited 2 time in scopus
Title
Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration
Other Titles
산호 (Sinularia brassica) 에서 분리된 Sesquiterpenoid 와 스테로이드 물질의 구조분석 및 항균활성 연구
Authors
Pham, Giang Nam
Kang, Da Yeun
Kim, Min Ju
Han, Se Jong
Lee, Jun Hyuck
Na, MinKyun
Subject
Pharmacology & Pharmacy
Keywords
Sinularia brassicasesquiterpenoidssteroidsantileishmanial activityantimicrobial activity
Issue Date
2021-09
Citation
Pham, Giang Nam, et al. 2021. "Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration". MARINE DRUGS, 19(9): 1-12.
Abstract
Two undescribed rearranged cadinane-type sesquiterpenoids (1-2), named sinulaketol A-B, together with one new chlorinated steroid (3), one new gorgosterol (4), one known sesquiterpene (5), one known dibromoditerpene (6) and two known polyhydroxylated steroids (7-8) were isolated from the soft coral Sinularia brassica. The structures of these compounds were established by extensive spectroscopic analysis, including HRESIMS, 1D, and 2D NMR spectroscopy. Their absolute configurations were also determined by the ECD calculations and DP4+ probability analysis. Antileishmanial activity of compounds 1-8 was evaluated in vitro against the amastigote forms of Leishmania donovani, in which compounds 3, 6, and 7 inhibited the growth of L. donovani by 58.7, 74.3, 54.7%, respectively, at a concentration of 50 mu M. Antimicrobial effect of the isolated compounds were also evaluated against Candida albicans, Staphylococcus aureus, and Escherichia coli. Compound 6, a brominated diterpene, exhibited antimicrobial effect against S. aureus.
URI
https://repository.kopri.re.kr/handle/201206/13593
DOI
http://dx.doi.org/10.3390/md19090523
Type
Article
Station
King Sejong Station
Indexed
SCIE
Appears in Collections  
2021-2021, Development of potential candidates as antibiotics based on polar genetic resources (21-21) / Lee, Jun Hyuck (PM21030)
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