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Antiinflammatory lanostane triterpenoids from Ganoderma lucidum

Cited 7 time in wos
Cited 1 time in scopus
Title
Antiinflammatory lanostane triterpenoids from Ganoderma lucidum
Other Titles
Ganoderma lucidum 로부터 항염증의 라노스탄 트라이터페노이드
Authors
Koo, Man Hyung
Chae, Hae-Jung
Lee, Jun Hyuck
Suh, Sung-Suk
Youn, Ui Joung
Subject
ChemistryPharmacology & Pharmacy
Keywords
Ganoderma lucidumpolyporaceaelanostane triterpenoidinhibit nitric oxide production
Issue Date
2021-11-18
Citation
Koo, Man Hyung, et al. 2021. "Antiinflammatory lanostane triterpenoids from Ganoderma lucidum". NATURAL PRODUCT RESEARCH, 35(22): 1-8.
Abstract
Phytochemical and biological studies of the methanolic extracts from Ganoderma lucidum (Polyporaceae) have led to the identification and isolation of a new lanostane triterpenoid, ganosidone A (1), and its eight known derivatives (2-9). The structure of new compound was determined by HREIMS, 1 D and 2 D NMR experiments and by comparing the acquired physicochemical data with the published values. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharides (LPS) in mouse macrophage RAW 264.7 cells in vitro. Notably, at a concentration of 50 mu M, compounds 4 and 7 inhibited NO production by 86.5% and 88.2%, respectively.
URI
https://repository.kopri.re.kr/handle/201206/13607
DOI
http://dx.doi.org/10.1080/14786419.2019.1705815
Type
Article
Station
기타()
Indexed
SCIE
Appears in Collections  
2019-2019, Development of potential candidates as antibiotics based on polar genetic resources (19-19) / Lee, Jun Hyuck (PE19210)
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