KOPRI Repository

Wistin Exerts an Anti-Inflammatory Effect via Nuclear Factor-κB and p38 Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells

Cited 0 time in wos
Cited 0 time in scopus
Title
Wistin Exerts an Anti-Inflammatory Effect via Nuclear Factor-κB and p38 Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells
Other Titles
식물유래 화합물인 Wistin의 Nuclear Factor-кB 와 p38 신호전달을 통한 항염증 활성 기작확인
Authors
An, Jangeun
Ryu, Gyoungah
Shin, Seong-Ah
Kim, Huiji
Ahn, Mi-Jeong
Lee, Jun Hyuck
Lee, Chang Sup
Subject
Biochemistry & Molecular BiologyChemistry
Keywords
inflammationphytochemicalwistin
Issue Date
2022-09
Citation
An, Jangeun, et al. 2022. "Wistin Exerts an Anti-Inflammatory Effect via Nuclear Factor-κB and p38 Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells". MOLECULES, 27(17): 1-14.
Abstract
Inflammation is an immune response to cellular damage caused by various stimuli (internal or external) and is essential to human health. However, excessive inflammatory re-sponses may be detrimental to the host. Considering that the existing drugs for the treatment of inflammatory diseases have various side effects, such as allergic reactions, stomach ulcers, and cardiovascular problems, there is a need for research on new anti-inflammatory agents with low toxicity and fewer side effects. As 4′,6-dimethoxyisoflavone-7-O-β-d-glucopyranoside (wistin) is a phytochemical that belongs to an isoflavonoid family, we investigated whether wistin could potentially serve as a novel anti-inflammatory agent. In this study, we found that wistin signifi-cantly reduced the production of nitric oxide and intracellular reactive oxygen species in lipo-polysaccharide-stimulated RAW 264.7 cells. Moreover, wistin reduced the mRNA levels of pro-inflammatory enzymes (inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2)) and cytokines (interleukin (IL)-1β and IL-6) and significantly reduced the protein expression of pro-inflammatory enzymes (iNOS and COX-2). Furthermore, wistin reduced the activation of the nuclear factor-кB and p38 signaling pathways. Together, these results suggest that wistin is a prospective candidate for the development of anti-inflammatory drugs.
URI
https://repository.kopri.re.kr/handle/201206/13906
DOI
http://dx.doi.org/10.3390/molecules27175719
Type
Article
Station
해당사항없음
Indexed
SCIE
Appears in Collections  
2021 Polar Academic Program (PE21900)
Files in This Item

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse