Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong-Cheol | - |
dc.contributor.author | Cho, Kwang-Ho | - |
dc.contributor.author | Ko, Wonmin | - |
dc.contributor.author | Yoon, Chi-Su | - |
dc.contributor.author | Sohn, Jae Hak | - |
dc.contributor.author | Yim, Joung Han | - |
dc.contributor.author | Kim, Youn-Chul | - |
dc.contributor.author | Oh, Hyuncheol | - |
dc.date.accessioned | 2017-08-03T12:52:56Z | - |
dc.date.available | 2017-08-03T12:52:56Z | - |
dc.date.issued | 2016 | - |
dc.description.abstract | In the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus<em> Aspergillus</em> sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS) generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways. | - |
dc.language | English | - |
dc.subject | Biochemistry & Molecular Biology | - |
dc.subject | Chemistry | - |
dc.title | Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Kim, Dong-Cheol, et al. 2016. "Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines". <em>International Journal of Molecular Sciences</em>, 17: 529. | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 17 | - |
dc.citation.page | 529 | - |
dc.identifier.doi | 10.3390/ijms17040529 | - |
dc.subject.keyword | TMC-256C1 | - |
dc.subject.keyword | Aspergillus | - |
dc.subject.keyword | Marine fungus | - |
dc.subject.keyword | Neuroprotective effect | - |
dc.subject.keyword | Anti-neuroinflammatory effect | - |
dc.subject.keyword | Heme oxygenase-1 (HO-1) | - |
dc.identifier.scopusid | 2-s2.0-84962903621 | - |
dc.identifier.wosid | 000374585300108 | - |
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