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Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis

Cited 12 time in wos
Cited 15 time in scopus

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dc.contributor.authorYoun, Ui Joung-
dc.contributor.authorPark, Eun-Jung-
dc.contributor.authorKondratyuk, Tamara P.-
dc.contributor.authorSripisut, Tawanun-
dc.contributor.authorLaphookhieo, Surat-
dc.contributor.authorPezzuto, John M.-
dc.contributor.authorChang, Leng Chee-
dc.date.accessioned2017-08-03T12:52:57Z-
dc.date.available2017-08-03T12:52:57Z-
dc.date.issued2016-
dc.description.abstractBioassay-guided fractionation of the dichloromethane extract fromthe apical bud of <em>Gardenia sootepenesis </em>Hutch. (Rubiaceae) led to the isolation of four new cycloartane triterpenes, sootepins F?I (1?4), along with four known derivatives (5?8). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison of the physicochemical datawith published values. The isolates were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α)-induced nuclear factor kappa (NF-κB) activity. Compounds 6?8 inhibited TNF-α-induced NF-κB activity with half maximal inhibitory concentration (IC50) values of 8.3, 5.6, and 6.0 μM, respectively; compounds 7 and 8 showed significant NO-inhibitory activity with IC50 values of 3.2 and 2.0 μM, respectively.-
dc.languageEnglish-
dc.subjectPharmacology & Pharmacy-
dc.titleAnti-inflammatory triterpenes from the apical bud of Gardenia sootepensis-
dc.typeArticle-
dc.identifier.bibliographicCitationYoun, Ui Joung, et al. 2016. "Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis". <em>Fitoterapia</em>, 114: 92-97.-
dc.citation.titleFitoterapia-
dc.citation.volume114-
dc.citation.page92-97-
dc.identifier.doi10.1016/j.fitote.2016.08.012-
dc.subject.keywordGardenia sootepenesis-
dc.subject.keywordRubiaceae-
dc.subject.keywordCycloartane triterpenes-
dc.subject.keywordAnti-inflammatory activity-
dc.identifier.scopusid2-s2.0-84985000616-
dc.identifier.wosid000386643600014-
Appears in Collections  
2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han (PM11090; PM12030; PM13030; PM14050; PM15050)
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