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Characterization of Two AntimicrobialPeptides from Antarctic Fishes (Nototheniacoriiceps and Parachaenichthys charcoti)

Cited 13 time in wos
Cited 14 time in scopus
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Characterization of Two AntimicrobialPeptides from Antarctic Fishes (Nototheniacoriiceps and Parachaenichthys charcoti)
Other Titles
남극어류 (Notothenia coriiceps and Parachaenichthys charcoti) 로부터 확인한 항생펩타이드의 특성 확인
Shin, Seung Chul
Park, Hyun
Kim, Han-Woo
Lee, Jun Hyuck
Lee, Jong Eun
Lee, Yung Mi
Ahn, Do Hwan
Ahn, Inhye
Science & Technology - Other Topics
Notothenia coriiceps; Parachaenichthys charcoti; antimicrobial peptide
Issue Date
Shin, Seung Chul, et al. 2017. "Characterization of Two AntimicrobialPeptides from Antarctic Fishes (Nototheniacoriiceps and Parachaenichthys charcoti)". PLOS ONE, 12(1): 170821-NaN.
We identified two antimicrobial peptides (AMPs) with similarity to moronecidin in Antarctic fishes. The characteristics of both AMPs were determined using moronecidin as a control. Moronecidin, which was first isolated from hybrid striped bass, is highly salt-resistant, and possesses broad-spectrum activity against various microbes. The moronecidin-like peptide from Notothenia coriiceps exhibited a narrower spectrum of activity and a higher salt sensitivity than moronecidin. The AMP from Parachaenichthys charcoti exhibited similar antimicrobial activity to moronecidin, and similar salt sensitivity. In an experiment to identify toxic effects, both of the moronecidin-like peptides from the Antarctic fishes exhibited lower hemolytic activity than moronecidin. In spite of its low toxicity, the AMP from N. coriiceps is unlikely to be considered as a candidate for antibiotic development, owing to its narrow spectrum of activity and high salt sensitivity. In contrast, the high salt resistance and broad-spectrum activity of the AMP from P. charcoti could be more advantageous for clinical use than moronecidin, since it could kill bacteria under physiological conditions with low toxicity. A further comparison of these two AMPs from Antarctic fishes with other AMPs could help to reduce the toxicity of AMPs for clinical use.
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