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Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum

Cited 38 time in wos
Cited 41 time in scopus
Title
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum
Other Titles
남극 Stereocaulon alpinum 유래 PTP1B 저해효과를 가지는 depsidone 및 pseudodepsidone계 물질
Authors
Lee, Hong Kum
Ahn, Jong Seog
Oh, Hyuncheol
Yim, Joung Han
Sohn, Jae Hak
Seo, Changon
Subject
Pharmacology & PharmacyChemistry
Keywords
DepsidonesLichen metabolitesNon-competitive inhibitorsPTP1BStereocaulon alpinum
Issue Date
2009
Publisher
ELSEVIER
Citation
Lee, Hong Kum, et al. 2009. "Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum". BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1(19): 2801-2803.
Abstract
Seven phenolic lichen metabolites (1?7) have been isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. A depsidone-type compound, lobaric acid (1) and two pseudodepsidone-type compounds, 2 and 3, exhibited potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 0.87 lM, 6.86 lM, and 2.48 lM, respectively. Kinetic analyses of PTP1B inhibition by compounds 1 and 2 suggested that these compounds inhibited PTP1B activity in a non-competitive manner.
URI
https://repository.kopri.re.kr/handle/201206/6221
DOI
http://dx.doi.org/10.1016/j.bmcl.2009.03.108
Type
Article
Indexed
SCI
Appears in Collections  
2006-2010, Procurement and utilization of polar genetic resources (06-10) / Lee, Hong Kum; Yim, Joung Han (PE06050, PE07050, PE08050, PE09050, PE10050)
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