KOPRI Repository

PTP1B inhibitory secondary metabolites from the Antarctic lichen Lecidella carpathica

Cited 0 time in wos
Cited 15 time in scopus
Metadata Downloads
PTP1B inhibitory secondary metabolites from the Antarctic lichen Lecidella carpathica
Other Titles
남극 지의류 Lecidella carpathica dbfo PTP1B 저해제
Lee, Hong Kum
Yim, Joung Han
Seo, Changon
Oh, Hyuncheol
Antarctic lichen; Lecidella carpathica; competitive; lichen metabolites; protein tyrosine phosphatase 1
Issue Date
Taylor & Francis
Lee, Hong Kum, et al. 2011. "PTP1B inhibitory secondary metabolites from the Antarctic lichen Lecidella carpathica". Mycology(1): 18-23.
Protein tyrosine phosphatase 1B (PTP1B) is an attractive therapeutic target for diabetes, playing a major role in negative regulation of the insulin signaling pathway. Bioassay-guided investigations of an MeOH extract of the Antarctic lichen, Lecidella carpathica, afforded three PTP1B inhibitory metabolites: hopane-6α,22-diol (1), brialmontin 1 (2), and atraric acid (3), along with two aromatic metabolites (4 and 5) previously isolated from a different Antarctic lichen species. Their structures were determined by analysis of NMR and MS data. Compounds 1?3 inhibited PTP1B activity in a dose-dependent manner with IC50 values of 3.7, 14.0 and 51.5 μM, respectively, and kinetic analyses of PTP1B inhibition by compounds 1 and 2 suggested that these compounds inhibit PTP1B activity in a competitive manner. In addition, 6,22-hopanediol (1) displayed some selectivity toward PTP1B over other protein tyrosine phosphatases, such as TCPTP (IC50 = 8.4 μM), SHP-2 (IC50 > 68 μM), LAR (IC50 > 68 μM), and CD45 (IC50 > 68 μM).
Files in This Item
General Conditions
      ROMEO Green
    Can archive pre-print and post-print or publisher's version/PDF
      ROMEO Blue
    Can archive post-print (ie final draft post-refereeing) or publisher's version/PDF
      ROMEO Yellow
    Can archive pre-print (ie pre-refereeing)
      ROMEO White
    Archiving not formally supported

    Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.