KOPRI Repository

Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells

Cited 7 time in wos
Cited 7 time in scopus
Metadata Downloads
Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells
Other Titles
유사 마이코스포린 아미노산의 일종인 porphyra-334가 HaCaT세포에서 자외선에의해 야기되는 세포사멸 완화
Suh, Sung-Suk
Kim, Sanghee
Kim, Il-Chan
Lee, Sung Gu
Oh, Se Kyung
Pharmacology & Pharmacy
HaCaT cells; UV irradiation; apoptosis; cell proliferation; porphyra-334
Issue Date
Suh, Sung-Suk, et al. 2017. "Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells". ACTA PHARMACEUTICA, 67: 257-264.
The main aim of the current research was to study the effect of porphyra-334, one of mycosporine-like amino acids (MAAs) which are well known as UV-absorbing compounds, on UV-induced apoptosis in human immortalized keratinocyte (HaCaT) cells. Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have attracted considerable attention recently in both industry and research in pharmacology. Here, human HaCaT cells were used to determine the biological activities of porphyra-334 by various in vitro assays including proliferation, apoptosis, and Western blot assays. The proliferation rate of UV-irradiated HaCaT cells was significantly decreased compared with the control group. Pretreatment with porphyra-334 markedly attenuated the inhibitory effect of UV and induced a dramatic decrease in the apoptotic rate. Expression of active caspase-3 protein was increased in response to UV irradiation, while caspase-3 levels were similar between cells treated with porphyra-334 and the non-irradiated control group. Taken together, our data suggest that porphyra-334 inhibits UV-induced apoptosis in HaCaT cells through attenuation of the caspase pathway
Files in This Item
General Conditions
      ROMEO Green
    Can archive pre-print and post-print or publisher's version/PDF
      ROMEO Blue
    Can archive post-print (ie final draft post-refereeing) or publisher's version/PDF
      ROMEO Yellow
    Can archive pre-print (ie pre-refereeing)
      ROMEO White
    Archiving not formally supported

    Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.