KOPRI Repository

Epistatic Relationships of Two Regulatory Factors During Heterocyst Development

Cited 0 time in wos
Cited 0 time in scopus
Metadata Downloads
Epistatic Relationships of Two Regulatory Factors During Heterocyst Development
Kim, Young-Saeng
Kim, Il-Sup
Yoon, Ho-Sung
Kang, Sung-Ho
Life Sciences & Biomedicine - Other Topics
cellular differentiation; developmental genes; diffusible signal; epistatic relationship; mutual antagonistic regulation
Issue Date
Kim, Young-Saeng, et al. 2009. "Epistatic Relationships of Two Regulatory Factors During Heterocyst Development". The Korean Society Of Phycology, 24: 85-91.
The filamentous cyanobacterium Anabaena sp. Strain PCC 7120 produces a developmental pattern of single heterocystsseparated by approximately 10 vegetative cells. Heterocysts differentiate from vegetative cells and are specializedfor nitrogen fixation. The patS gene, which encodes a small peptide that inhibits heterocyst differentiation, isexpressed in proheterocysts and plays a critical role in establishing the heterocyst pattern. Another key regulator ofheterocyst development is the hetR gene. hetR mutants fail to produce heterocysts and extra copies of hetR on a plasmidcause a multiple contiguous heterocyst phenotype. To elucidate the relationship between these two counter actingfactors in the genetic regulatory pathway during heterocyst differentiation, the expression patterns of a patS-gfpand a hetR-gfp fusion were examined in a patS deletion and a hetR deletion strain. The results, in combination withthe result from a hetR and patS double deletion strain, suggest patS and hetR are mutually antagonistic and the balancebetween these two factors in two different cell types (heterocysts and vegetative cells) may be critical duringthe decision making process on their cell fates.
Files in This Item
General Conditions
      ROMEO Green
    Can archive pre-print and post-print or publisher's version/PDF
      ROMEO Blue
    Can archive post-print (ie final draft post-refereeing) or publisher's version/PDF
      ROMEO Yellow
    Can archive pre-print (ie pre-refereeing)
      ROMEO White
    Archiving not formally supported

    Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.