Bioactivities of ethanol extract from the Antarctic freshwater microalga, Chloromonas sp.
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- Bioactivities of ethanol extract from the Antarctic freshwater microalga, Chloromonas sp.
- Other Titles
- 남극 담수미세조류 Chloromonas sp.의 에탈올 추출물의 생물학적 활성
- Suh, Sung-Suk
Han, Se Jong
Youn, Ui Joung
Lee, Sung Gu
Yang, Eun Jin
- Chloromonas sp; anti-cancer therapy; anticancer activity; cancer
- Issue Date
- Suh, Sung-Suk, et al. 2017. Bioactivities of ethanol extract from the Antarctic freshwater microalga, Chloromonas sp.. Polar symposium. 극지연구소. 2017.05.17~2017.05.17.
- Cancer is the principal cause of human death and occurs through highly complex processes that involve the multiple coordinated mechanisms of tumorigenesis. A number of studies have indicated that the microalgae extracts showed anticancer activity in a variety of human cancer cells and can provide a new insight in the development of novel anti-cancer therapy. Here, in order to investigate molecular mechanisms of anticancer activity in the Antarctic freshwater microalga, Chloromonas sp., we prepared ethanol extract of Chloromonas sp. (ETCH) and performed several in vitro assays using human normal keratinocyte (HaCaT) and different types of cancer cells including cervical, melanoma, and breast cancer cells (HeLa, A375 and Hs578T, respectively). We revealed that ETCH caused significant cell growth inhibition and apoptosis of cancer cells in a dose-dependent manner, whereas it showed no anti-proliferation to normal cells. In addition, ETCH had a significant inhibitory effect on cell invasion without the cytotoxic effect. Furthermore, ETCH-induced apoptosis was mediated by increase in pro-apoptotic proteins including cleaved caspase-3 and p53, and by decrease in anti-apoptotic protein, Bcl-2 in ETCH-treated cancer cells. Taken together, this work firstly explored the antioxidant and anticancer activities of an Antarctic freshwater microalga, and ETCH could be a potential therapeutic candidate in the treatment of human cancer.
- Conference Name
- Polar symposium
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- Conference Date
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