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Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins

Cited 5 time in wos
Cited 10 time in scopus
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Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins
Other Titles
Shigella 균의 invasin 단백질에 의한 숙주감염시 세포골격 재형성에 관한 분자기작
Lee, Jun Hyuck
Yong Ho Park
HaJeung Park
Shigella; actin; bacillary dysentery; bacterial proteins; invasin; review
Issue Date
Lee, Jun Hyuck, Yong Ho Park, HaJeung Park. 2014. "Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins". INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 15(10): 18253-18266.
Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria such as Shigella, Listeria, enteroinvasive E. coli, and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2, and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells.
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