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Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

Cited 7 time in wos
Cited 8 time in scopus
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dc.contributor.authorKim, Dong-Cheol-
dc.contributor.authorOh, Hyuncheol-
dc.contributor.authorKim, Youn-Chul-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorSohn, Jae Hak-
dc.contributor.authorYoon, Chi-Su-
dc.contributor.authorKo, Wonmin-
dc.contributor.authorCho, Kwang-Ho-
dc.date.accessioned2018-03-29T06:15:24Z-
dc.date.available2018-03-29T06:15:24Z-
dc.date.issued2016-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/7510-
dc.description.abstractIn the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus Aspergillus sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS) generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways.-
dc.languageEnglish-
dc.titleAnti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines-
dc.typeArticle-
dc.identifier.bibliographicCitationKim, Dong-Cheol, et al. 2016. "Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines". <em>INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</em>, 17(4): 529-546.-
dc.citation.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.citation.volume17-
dc.citation.number4-
dc.identifier.doi10.3390/ijms17040529-
dc.citation.startPage529-
dc.citation.endPage546-
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2014:46.206-
dc.subject.keywordAspergillus-
dc.subject.keywordTMC-256C1-
dc.subject.keywordanti-neuroinflammatory effect-
dc.subject.keywordheme oxygenase-1 (HO-1)-
dc.subject.keywordmarine fungus-
dc.subject.keywordneuroprotective effect-
dc.identifier.localId2016-0301-
dc.identifier.scopusid2-s2.0-84962903621-
dc.identifier.wosid000374585300108-
Appears in Collections  
2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han
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