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Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum

Cited 8 time in wos
Cited 8 time in scopus
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Title
Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum
Other Titles
남극지의류(스테레오카울론)유래 이차대산물인 로바릭산, 로바스틴의 대장암과 자궁경부암에 대한 항암활성
Authors
Hong, Ju-Mi
Suh, Sung-Suk
Kim, Tai Kyoung
Kim, Jung Eun
Han, Se Jong
Youn, Ui Joung
Yim, Joung Han
Kim, Il-Chan
Subject
Biochemistry & Molecular Biology; Chemistry
Keywords
antartic lichen; apoptosis; cell cycle arrest; human cervix adenocarcinoma; human colon carcinoma; lobaric acid; lobarstin
Issue Date
2018-03
Citation
Hong, Ju Mi, et al. 2018. "Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum". MOLECULES, 23(3): 658-658.
Abstract
Lobaric acid and lobarstin, secondary metabolites derived from the antarctic lichen Stereocaulon alpnum, exert various biological activities, including antitumor, anti-proliferation, anti-inflammation, and antioxidant activities. However, the underlying mechanisms of these effects have not yet been elucidated in human cervix adenocarcinoma and human colon carcinoma. In the present study, we evaluated the anticancer effects of lobaric acid and lobarstin on human cervix adenocarcinoma HeLa cells and colon carcinoma HCT116 cells. We show that the proliferation of Hela and HCT116 cells treated with lobaric acid and lobarstin significantly decreased in a dose- and time-dependent manner. Using flow cytometry analysis, we observed that the treatment with these compounds resulted in significant apoptosis in both cell lines, following cell cycle perturbation and arrest in G2/M phase. Furthermore, using immunoblot analysis, we investigated the expression of cell cycle and apoptosis-related marker genes and found a significant downregulation of the apoptosis regulator B-cell lymphoma 2 (Bcl-2) and upregulation of the cleaved form of the poly (ADP-ribose) polymerase (PARP), a DNA repair and apoptosis regulator. These results suggest that lobaric acid and lobarstin could significantly inhibit cell proliferation through cell cycle arrest and induction of apoptosis via the mitochondrial apoptotic pathway in cervix adenocarcinoma and colon carcinoma cells. Taken together, our data suggests that lobaric acid and lobarstin might be novel agents for clinical treatment of cervix adenocarcinoma and colon carcinoma.
URI
https://repository.kopri.re.kr/handle/201206/10512
DOI
http://dx.doi.org/10.3390/molecules23030658
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