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Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity

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Title
Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity
Other Titles
영지버섯(Ganoderma lucidum)으로 부터 분리한 이차대사산물 및 이들의 항 염증 활성
Authors
Kim, Hyunji
Koo, Man Hyung
Lee, Jun Hyuck
Suh, Sung-Suk
Youn, Ui Joung
Subject
Pharmacology & Pharmacy
Keywords
Anti-inflammatory; Ganoderma lucidum; Lanstane triterpenoid; Polyporaceae
Issue Date
2019-09
Citation
Kim, Hyunji, et al. 2019-09. "Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity". Korean Journal of Pharmacognosy, 50(3): 232-238.
Abstract
Phytochemical study of Ganoderma lucidum (Polyporaceae) let to the isolation of five lanostane triterpenoid (1-5), along with two nitrogen derived phenolic compounds, N-phenylethylformamide (6) and N-acetylphenethylamine (7). The structures of the compounds were determined by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Compounds 6 and 7 were isolated for the first time from the genus Ganoderma and this species. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Among the isolates, compounds 2 and 3 showed moderate inhibitory activity against NO production.
URI
https://repository.kopri.re.kr/handle/201206/10837
DOI
http://www.koreascience.or.kr/article/JAKO201928951542984.page
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