Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines
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Title
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Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines
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Authors
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Kim, Dong-Cheol
Cho, Kwang-Ho
Ko, Wonmin
Yoon, Chi-Su
Sohn, Jae Hak
Yim, Joung Han
Kim, Youn-Chul
Oh, Hyuncheol
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Subject
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Biochemistry & Molecular Biology; Chemistry
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Keywords
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TMC-256C1; Aspergillus; Marine fungus; Neuroprotective effect; Anti-neuroinflammatory effect; Heme oxygenase-1 (HO-1)
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Issue Date
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2016
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Citation
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Kim, Dong-Cheol, et al. 2016. "Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines". International Journal of Molecular Sciences, 17: 529.
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Abstract
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In the course of searching for bioactive secondary metabolites from marine fungi,
TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus Aspergillus sp.
SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by
lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity
in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to
oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS)
generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells.
Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were
associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of
nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1
activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase
(PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1
activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of
the p38 MAPK and PI3K/Akt pathways.
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DOI
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http://dx.doi.org/10.3390/ijms17040529
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Type
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Article
- Appears in Collections
- 2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han (PM11090; PM12030; PM13030; PM14050; PM15050)
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