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Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island

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Title
Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island
Other Titles
남극 세종과학기지 주변에 서식하는 지의류 추출물의 항면역 효과
Authors
Min, Seul Ki
Kim, Jung Eun
Hong, Ju-Mi
Yim, Joung Han
Park, Hyun
Youn, Ui Joung
Han, Se Jong
Kim, Il-Chan
Subject
Biotechnology & Applied Microbiology
Keywords
Lecania gerlachei; lichens; Antarctica; anti-inflammatory properties; nuclear factor kappa B (NF-κB) pathway
Issue Date
2020-08
Citation
Min, Seul Ki, et al. 2020. "Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island". BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 25(4): 543-550.
Abstract
Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the evelopment of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopolysaccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1β and 1α (IL-6, IL-1β and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.
URI
https://repository.kopri.re.kr/handle/201206/11873
DOI
http://dx.doi.org/10.1007/s12257-019-0371-4
Appears in Collections  
2020-2020, Commercialization of new Biomaterials from polar organisms (20-20) / Yim, Joung Han (PE20010)
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